Eyedropper Tool picks a color directly from the canvas and makes it the current drawing color. It is essential when you want to reuse an exact color that is already in the artwork.

Flip Tool lets you flip content horizontally or vertically. It is useful when you want to create mirrored variations quickly or reverse the direction of a part without redrawing it.

Hand Tool lets you drag the canvas to change what part of it is visible. It is useful when you are zoomed in on a large canvas and want to look around quickly.

Shape Tool is for placing clean rectangles, circles, triangles, and straight lines. It is useful for outlines that are hard to align by hand, as well as UI parts and symbol work.

Arrow Tool is used to move a selection or an entire layer. It is not for drawing; it is for alignment and small positional adjustments.

Merge Colors lets you reduce the number of colors while choosing exactly which colors should be combined. It is better than automatic reduction when you want to preserve your own intent while trimming the palette.

Hue / Saturation is for quickly adjusting the overall color feel of the image. It is useful when you want to shift the mood a little or create color variations from the same artwork.

Eraser Tool is the basic tool for turning drawn pixels back into transparency. It works for both tiny one-pixel cleanup and larger erasing with a broader brush.

Selection Tool is used when you want to define an editable area or cut something out. It offers three methods: rectangle selection, freehand selection, and automatic selection based on similar colors.

Bucket Tool is used to process a closed area all at once. In addition to normal fill, it also supports erase fill and dithering fill.